In 2008, a group led by Prof. Marcos Tobias-Machado, initiated a research series involving the role of the human epidermal growth factor receptor extracellular domain (HER-2/neu) in patients with prostate cancer. First, in an initial sample of 30 patients, there was found to be a strong...
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant digestive tumor with a very poor prognosis. Hypoxia-inducible transcription factor-1α (HIF-1α) is involved in malignant progression in many solid tumors, including PDAC, upregulation of HIF-1α accelerates PDAC progression, but the...