Research shows interaction of tau and amyloid-beta in the brain may cause cognitive decline For years, Alzheimer's researchers have focused on two proteins that accumulate in the brains of people with Alzheimer's and may contribute to the disease: plaques made up of the protein amyloid-beta, and...
Blood offers promise as a way to detect Alzheimer's disease at its earliest onset, Mayo Clinic researchers say. They envision a test that would detect distinct metabolic signatures in blood plasma that are synonymous with the disease - years before patients begin showing cognitive decline. Their...
Anti-cancer drug bexarotene (Tagretin), which had extremely promising results in reversing Alzheimer's disease symptoms in mice last year, was found not to be as promising in later trials, according to articles published in the journal Science. In other words, scientists have not able to fully...
SELF EXAMINATION FOR ALZHEIMER'S DISEASE.......It takes less than 15 seconds...
If you are over 45 yrs old, you SHOULD take this Alzheimer's Test
How fast can you guess these words and fill-in the blanks?
1. _ _NDOM
2. F_ _K
3. P_N_S
4. PU_S_
5. S_X
6. BOO_S...
New light has been shed on how neuronal metabolism relates to the development of Alzheimer's disease in a recent study. The research was conducted by scientists from Karolinska Institutet in Sweden and was published in the journal Proceedings of the National Academy of Sciences (PNAS)...
Alzheimer's disease has two key hallmarks: accumulation of amyloid protein plaques outside brain cells and of neurofibrillary tangles of tau protein inside brain cells. The plaques appear first, and then the tangles, giving the impression that one causes the other. However, evidence of this is...
A randomized controlled trial by Kaisu H. Pitkala, M.D., Ph.D., of the University of Helsinki, Finland, and colleagues suggests an intensive and long-term exercise program has beneficial effects on the physical functioning of patients with Alzheimer Disease without increasing costs of health and...
Researchers at the University of Miami Miller School of Medicine collaborated with an international team to identify a new gene associated with Alzheimer's disease in African Americans. Published April 10 in the prestigious Journal of the American Medical Association, their study, "Variants in...
The very serious hereditary disease HDLS was discovered in 1984 in Sweden. Many HDLS patients are still incorrectly diagnosed with Alzheimer's disease, MS or Parkinson's disease, but researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden, have now developed a more certain...
Women who abruptly and prematurely lose estrogen from surgical menopause have a two-fold increase in cognitive decline and dementia. "This is what the clinical studies indicate and our animal studies looking at the underlying mechanisms back this up," said Brann, corresponding author of the...
Long term treatment by carmustine, a chemical relative of mustard gas and already used to treat some types of brain cancer, can decrease the amount of amyloid β and number of amyloid plaques in a mouse model of Alzheimer's disease. The research is published in Biomed Central's open access...
Working with a group from Nagasaki University, a research group at the Center for iPS Cell Research and Application (CiRA) at Japan's Kyoto University has announced in the online publication of Cell Stem Cell that it has successfully modeled Alzheimer's disease (AD) using both familial and...
In an effort to treat and identify Alzheimer's patients early on during the disease, the FDA says it may relax the guidelines on Alzheimer's early-stage trials. The Agency has issued a proposal designed to help researchers and developers find new treatments for patients before the onset of overt...
A research team composed of University of Kentucky researchers has published a paper which provides the first direct evidence that activated astrocytes could play a harmful role in Alzheimer's disease. The UK Sanders-Brown Center on Aging has also received significant new National Institutes of...
Researchers in Canada have discovered a drug originally intended for the treatment of diabetes may restore memory in brain cells affected by Alzheimer's disease. In tests on animal brain cells, they found that AC253, a diabetes drug that never made it to market, restored memory to levels...
A recent study finds that galantamine has a much lower mortality rate among patients with mild to moderately severe Alzheimer's disease compared to placebo. The findings were presented at the American College of Neuropsychopharmacology 51st Annual Meeting in Hollywood, and come from a study...
The discovery of the molecular pathway that drives the changes seen in the brains of Alzheimer's patients is reported, revealing new targets for drug discovery that could be exploited to combat the disease. The study gives the most detailed understanding yet of the complex processes leading to...
A large-scale international study involving French researchers from the Inserm-Institut Pasteur Lille-Universite Lille Nord de France "Public health and molecular epidemiology of ageing-related diseases" joint research unit led by Philippe Amouyel, has just discovered a gene for susceptibility...
Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson's disease from binding together and killing the brain's neurons. Building on those findings, they have now turned their attention to Alzheimer's...
An efficient, high-volume technique for testing potential drug treatments for Alzheimer's disease uncovered an organic compound that restored motor function and longevity to fruit flies with the disease, according to new research that could help put the search for an effective Alzheimer's drug...