In the online version of Clinical Cancer Research, a group of investigators from Takeda laboratories address androgen signal transduction in castration-resistant prostate cancer (CRPC). They note that despite castrate levels of testosterone, androgens can be measured in the tissues of patients...
For instance, it is said that some companies sell printers cheaply. They then design them to be ink guzzlers and the replenishment of ink is exclusive to the inks they provide - expensively.