When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die - the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even in the face of p53 reactivation create more of the protein p21 than the...
In studies conducted on the fruit fly, researchers at IRB Barcelona headed by ICREA Professor Marco Milan have revealed that organs have the molecular mechanisms to control their proportions. In this process the protein p53 plays a crucial role. The study is published in the prestigious journal...
The p53 tumor suppressor gene, the "guardian of the genome," protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of proteins that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal...