Cholesterol plays a key role in regulating proteins involved in cell signaling and may be important to many other cell processes, an international team of researchers has found. The results of their study are reported in the journal Nature Communications. Cholesterol's role in heart disease has...
The Japanese diet has long been lauded as one of the healthiest on the planet, yielding a population with high longevity and low rates of heart disease, diabetes and obesity. Despite that, shocking new statistics indicate that their health is taking a turn for the worse, with 29% of Japanese...
There are numerous specialized growth factors that are responsible for cells of different tissues of our body to divide and differentiate when needed. These hormone-like factors bind to matching receptors on the surface of their target cells and thus give order for the cell to divide. However, a...
In a new study published in the August 16th issue of Developmental Cell, researchers at NYU Langone Medical Center identified a molecular mechanism that guarantees that new blood vessels form in the right place and with the proper abundance. "We have known for a long time that blood vessels...
Researchers at New York University's Department of Chemistry and NYU Langone Medical Center have developed a compound that blocks signaling from a protein implicated in many types of cancer. The compound is described in the latest issue of the journal Nature Chemical Biology. The researchers...
T-ing up a new target for Parkinson's disease treatment Parkinson disease (PD) affects 1-2% of the population over the age of 65 years. It results from loss or loss of function of nerve cells in the brain that coordinate movement. As a result, the hallmark symptoms of PD are trembling in hands...
In the online version of Clinical Cancer Research, a group of investigators from Takeda laboratories address androgen signal transduction in castration-resistant prostate cancer (CRPC). They note that despite castrate levels of testosterone, androgens can be measured in the tissues of patients...
Cholangiocarcinoma (CCA), a bile duct cancer, is one of the major cancers in Northeast Thailand. This cancer is difficult to diagnose and has high metastatic and mortality rates. Overexpression of Met, a hepatocyte growth factor (HGF) receptor, has frequently been found in CCA and is correlated...
The early stages of Alzheimer's disease are thought to occur at the synapse, since synapse loss is associated with memory dysfunction. Evidence suggests that amyloid beta (Aβ) plays an important role in early synaptic failure, but little has been understood about Aβ's effect on the plasticity...