Nearly two-thirds of patients with high-risk neuroblastoma - a common tumor that forms in the nerve cells of children - cannot be cured using tumor-killing cancer drugs. A study published by Cell Press in the journal Chemistry & Biology reveals a new genomic approach to screen for compounds that...
Different brain areas are activated when we choose to suppress an emotion, compared to when we are instructed to inhibit an emotion, according a new study from the UCL Institute of Cognitive Neuroscience and Ghent University. In this study, published in Brain Structure and Function, the...
Pain is an undeniable focal point for patients with sickle cell disease but it's not the best focus for drug development, says one of the dying breed of physicians specializing in the condition. Rather scientists need to get back to the crux of the disease affecting 1 in 500 black Americans and...
Research led by Queen Mary, University of London, has shown that recovery from chronic fatigue syndrome (CFS) is possible for some patients, and has identified two treatments most likely to lead to recovery. The latest results from the PACE trial* show that cognitive behaviour therapy (CBT) and...
When the era of regenerative medicine dawned more than three decades ago, the potential to replenish populations of cells destroyed by disease was seen by many as the next medical revolution. However, what followed turned out not to be a sprint to the clinic, but rather a long tedious slog...
Identification Of Mitochondrial "Gatekeeper" Protein May Eventually Lead To Therapies
Researchers at Temple University's Center for Translational Medicine and the University of Pennsylvania have identified a protein that serves as a gatekeeper for controlling the rush of calcium into the cell's...
University of Iowa researchers have previously shown that an enzyme called CaM kinase II plays a pivotal role in the death of heart cells following a heart attack or other conditions that damage or stress heart muscle. Loss of beating heart cells is generally permanent and leads to heart...
Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent cocaine from producing physiological effects, and could aid in the...
Researchers reporting online in Current Biology, a Cell Press publication, have for the first time shown that they can control the behavior of monkeys by using pulses of blue light to very specifically activate particular brain cells. The findings represent a key advance for optogenetics, a...
Scientists at the Gladstone Institutes have for the first time transformed skin cells - with a single genetic factor - into cells that develop on their own into an interconnected, functional network of brain cells. The research offers new hope in the fight against many neurological conditions...
The drug rapamycin has been shown to extend lifespan in lab animals, yet rapamycin has also been linked to impaired glucose tolerance and insulin sensitivity, two hallmarks of diabetes. By teasing apart rapamycin's activity at the cellular level, researchers at Whitehead Institute and the...
"Face recognition is an important social skill, but not all of us are equally good at it," says Beijing Normal University cognitive psychologist Jia Liu. But what accounts for the difference? A new study by Liu and colleagues Ruosi Wang, Jingguang Li, Huizhen Fang, and Moqian Tian provides the...
Proteins are the molecular machines of the cell. They transport materials, cleave products or transmit signals- and for a long time, they have been a main focus of attention in molecular biology research. In the last two decades, however, another class of critically important molecules has...
The American Journal of Pathology published the first report of the presence of alternative lengthening of telomeres (ALT) that can be used as a diagnostic indicator and could be significant for developing anti-cancer therapies for cancers in the bladder, cervix, endometrium, esophagus...
The truth is...not all pain is created equal. Acute pain is where it all begins. Lasting for several months, acute pain is typically treated with rest, time and medication. For many, that is enough. But if the pain persists, it converts to chronic pain, and new methods must be explored...
Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that growth in the leukemia market will be driven mostly by chronic myelogenous leukemia (CML) therapies (Novartis's Gleevec and Tasigna and Bristol-Myers Squibb's Sprycel)...
The Florida Biomedical Research Program has awarded $2 million in biomedical research grants to three scientists from the Florida campus of The Scripps Research Institute...
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Stalled health care reform efforts have created several unresolved issues, some of which related to Medicare and Medicaid. The Hill: "Medicare beneficiaries face a steep cliff in their coverage for physical therapy and similar treatments due to Congress's failure to enact a healthcare...