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Message: <blockquote data-quote="levdubya" data-source="post: 1066628" data-attributes="member: 461703">It would be better to take her with you.  Cats don't like their routines interrupted, but it's going to be interrupted, so it's better that she is at least with you.There are small disposable litter boxes that should fit on the floor of your car.  You might consider getting one for each way.Your vet can probably prescribe a light sedative to keep your cat calm/asleep for the duration of the trip.And lastly, it's not a good idea to have your kitty loose in the car while your driving.  She could get caught in something, or wiggle under the brake pedal.  Consider keeping her in her carrier or a small cage during the trip.</blockquote>