UroToday.com - Tumor hypoxia plays a role in tumor progression and chemotherapy resistance through reduced apoptosis, increased proliferation and angiogenesis. Hypoxic cell metabolism switches to anaerobic glycolysis and the production of acidic metabolites that facilitate cell survival and tumorigenesis. The pH of solid tumors is more acidic than normal tissue and impairs the uptake of weakly basic chemotherapeutic drugs. The group of Professor R. W. G...
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