A group of researchers from the University of Wisconsin-Madison has pinpointed a gene that confers diabetes susceptibility in obese mice. Published in the open-access journal PLoS Genetics, this study also shows that its protein tomosyn-2 acts as a brake on insulin secretion from the pancreas. "It's too early for us to know how relevant this gene will be to human diabetes," says Alan Attie, who leads the group, "but the concept of negative regulation is one of the most interesting things to come out of this study and that very likely applies to humans...
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