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Message: <blockquote data-quote="Rosalie" data-source="post: 2647693" data-attributes="member: 102312">You might want to stick with Frontline - I'm not sure I would put Advantage on a Collie mix. The active ingredient in Frontline does not go into the dog's organs otehr than it's skin layer. At that weight, you can still get away with the smaller dose, so long as there isn't a heavy infestation. If there is, you can go for the larger dose, but err on the side of safety if your dog has never used it before, at least at first. No sense asking for more trouble. Collies aren't the only breed to have the MDR-1 gene defect - it may be worth it to have her tested, just so you know - it can save your dog's life:http://www.vetmed.wsu.edu/depts-vcpl/</blockquote>