This is a job interview. Do not talk about your family, your house, your kids, your score at the last flea market you shopped.
Talk about your job experience that relates to what they are looking for in this job. Re-read the employment offer and think of specific things you have done that show you not only know how, you can do it easy and better than the losers out in the lobby. If you are trying to go into a different career, then talk about what you can do for them "I can create and update spreadsheets for any data files, using formulas and formatting to get the most out of the information."