Although survival in children with acute lymphoblastic leukaemia has improved dramatically in the past few decades, this has not been the case for those who relapse. In a trial that compared the chemotherapeutic agents mitoxantrone with idarubicin in a radically different approach to treatment, mitoxantrone conferred a significant benefit in progression-free and overall survival. In fact, the difference in survival between the two study groups was so noticeable that the authors stopped recruiting children into the trial much earlier than planned...
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