NEUROBIOLOGY: Common mechanism for more than 50% of cases of hereditary spastic paraplegia Hereditary spastic paraplegia (HSP) is the name given to a group of inherited neurological disorders characterized by progressive stiffness or tightness of the muscles (spasticity) in the lower limbs. Although mutations at over 40 genetic sites have been shown to cause HSP, more than 50% of HSP cases are caused by mutations in one of just three genes: SPG3A, which makes the protein atlastin-1; SPG31, which makes the protein REEP1; and SPG4, which makes the protein spastin...
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