Tweaking the levels of factors used during the reprogramming of adult cells into induced pluriopotent stem (iPS) cells greatly affects the quality of the resulting iPS cells, according to Whitehead Institute researchers. "This conclusion is something that I think is very surprising or unexpected that the levels of these reprogramming factors determine the quality of the iPS cells," says Whitehead Founding Member Rudolf Jaenisch. "We never thought they'd make a difference, but they do." An article describing this work is published in the December 2 issue of Cell Stem Cell...
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