Gaucher's (Gaucher) disease, also known as glucocerebrosidase deficiency, occurs when a certain lipid, glucosylceramide, accumulates in the bone marrow, lungs, spleen, liver and sometimes the brain. Patients with Gaucher's disease have a hereditary deficiency of glucocerebrosidase, an enzyme that helps the body process glucosylceramide. Glucosylceramide is also known as glucocerebroside. When glucocerebrosidase is faulty, the lipid (fat) glucosylceramide builds up, especially in the macrophages. Macrophage is a type of white blood cell...
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