Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health. They are benign tumors that occur in 60% of women by the age of 45 years and cause symptoms such as abdominal pain and discomfort, and abnormal bleeding in about half of the cases. Fibroids are also an important cause of infertility. These tumors are the most common medical reason for hysterectomy. Considering the clinical importance of fibroids, relatively little has been known about the mechanisms of tumorigenesis involved...
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