Cost-utility analyses of new biotechnologies are often conducted under best-practice hypotheses; there exists a need to examine the robustness of these analyses in the real-health practice setting. Oncotype DX® (Genomic Health, Inc. Redwood City, CA), a 21-gene assay, was clinically validated as an accurate predictor of 10-year recurrence-free survival and patient's response to treatment among the early-stage estrogen-receptor-positive, lymph-node-negative breast cancer (ER+ LN- ESBC) population... 
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