As long as you give each muscle group 48-72 hours in between and you aren't lifting to failure. I don't have any problems doing a 3-way body split. Day 1 & 4 are chest, tricep. lat, Day 2 & 5 are thigh, bicep & back... and day 3 & 6 are core, traps & shoulders, calves. Day 7 is my rest day. I chose a push and a pull type exercise for each muscle group so I'm doing one of each type once a week.