A second high-profile paper in as many months has found an important role in learning and memory for calpain, a molecule whose academic fortunes have ebbed and flowed for 25 years. USC's Michel Baudry (then at the University of California, Irvine) and Gary Lynch (UC Irvine) first pointed to calpain as the key to memory in a seminal 1984 paper in Science on the biochemistry of memory. In a paper published Jan. 20 in the Journal of Neuroscience, Baudry and graduate student Sohila Zadran report that calpain mediates the effects of brain-derived neurotrophic factor (BDNF)... 
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