In new draft guidance, published today, NICE has not been able to recommend dasatinib, high-dose imatinib or nilotinib for the treatment of CML (chronic myeloid leukaemia) that is resistant to standard-dose imatinib. In response to the draft guidance Andrew Dillon, Chief Executive at NICE, said: "The evidence for the effectiveness of dasatinib, high-dose imatinib and nilotinib is very weak. When we recommend the use of very expensive treatments, we need to be confident that they bring sufficient additional benefit to justify their cost... 
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