Underlying all forms of diabetes is dysfunction of cells in the pancreas known as beta cells. The dysfunction is, in part, a result of inflammation mediated by soluble immune molecules known as cytokines. Greater understanding is needed of the molecular mechanisms by which beta cells respond to cytokines if protective therapeutics are to be developed. Insight into this issue has now been generated in mice by researchers, led by Raghavendra G. Mirmira, at Indiana University School of Medicine, Indianapolis, who have identified a crucial role in this response for the protein eIF5A...
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