UroToday.com - Adult bone marrow-derived mesenchymal stem cells (MSC) have been shown to inhibit tumor growth in various studies. Although MSC express MHC class I molecules, they lack expression of co-stimulatory molecules and suppress T-cell response, which gives them the utility to overcome a wide range of immunologic barriers. Additionally the ability of MSCs to home in on the sites of tumor growth is well known as their plasticity allows them to differentiate into bone, cartilage, fat, muscle, neurons and other tissue types...
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