What is the difference between a Lexus IS & an ISF? ?

yes, it is.

IS-F = 8-Speed Auto (0.1 ms shifting), 5.0l engine pumping out 416hp

IS250 = 6-Speed Auto/Manual, 2.5l engine pumping out 205hp

IS350 = 6-Speed Auto, 3.5l engine pumping out 306hp

The IS-F is to the IS as the M3 is to the 3 Series
 
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