The mammalian target of rapamycin (mTOR) inhibitor everolimus given with the aromatase inhibitor exemestane markedly boosts progression-free survival (PFS) in post-menopausal women with advanced breast cancer compared with hormonal therapy alone, according to updated results of the phase III Breast Cancer Trials of Oral Everolimus (BOLERO)-2 study reported at the 34th Annual San Antonio Breast Cancer Symposium (SABCS). An earlier analysis showed a significant PFS benefit when everolimus was added to exemestane. Gabriel N...
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