In Genesis 3:15, God promises that a seed of Eve will stomp the head of the serpent -- an injury more serious than the bruised heel it caused humanity. This is a promise, and a prophesy, of a descendant of Eve, Jesus Christ, who will come and will defeat the serpent.
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Genesis 3:15 (King James Version)
http://www.biblegateway.com/passage/?search=Genesis%203:15&version=KJV
And I will put enmity between thee and the woman, and between thy seed and her seed; it shall bruise thy head, and thou shalt bruise his heel.
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