Overexpression of the ARD1A gene (arrest-defective protein 1225) in mice reduced the number and size of both primary tumors and metastases, researchers report in a new study published online March 1 in the Journal of the National Cancer Institute. ARD1A blocks the expression of VEGFA (vascular endothelial growth factor A), an important mediator of blood vessel growth in tumors. It regulates VEGFA expression indirectly by acetylating the transcription factor that induces VEGFA expression - hypoxia inducible factor 1(HIF-1α)...
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