honestly it depends on what you are saying yes or no too. but i can personally say no won't lead you to a better path, exsecially when you are younger. if you are a tennager go ahead && expirment a little. say yes && no to stuff. it never hurts to make a mistake, you learn from it. so sometimes screwing up helps you makes decissions on bigger stuff latter on.
[i know i am not that old yet, but i've seen how fu cking helps you sometimes.]