This verse is related to Jesus' teachings about dedicating our lives to serving Him instead of ourselves,something almost no Christians do.The verses below explain His teachings on this topic in more detail.
Matthew 10:35-39 (Amplified Bible)
35For I have come to part asunder a man from his father, and a daughter from her mother, and a newly married wife from her mother-in-law.36And a man's foes will be they of his own household.37He who loves [and takes more pleasure in] father or mother more than in Me is not worthy of Me; and he who loves [and takes more pleasure in] son or daughter more than in Me is not worthy of Me;38And he who does not take up his cross and follow Me [cleave steadfastly to Me, conforming wholly to My example in living and, if need be, in dying also] is not worthy of Me.39Whoever finds his [lower] life will lose it [the higher life], and whoever loses his [lower] life on My account will find it [the higher life].
This verse offers further explanation:
Matthew 6:21
Your heart will always be where your treasure is.:you are looser: