Im not sure what creative speaker setup you are mentioning but, the only way to run a real indipendent 6 channel direct 5.1 setup tru one cable is digital, then encodeing it with dolby or DTS, if not it will be fake 5,1 with out direct channels, the outher solution is a 5.1 analog cable ( orange green and black) if you use 1 analog cable it will give you 5,1 but not real 5.1
but any creative speaker system that supports optical /digital will work with 1 cord.
(this is not incl recever system setups that use one cord. but that is fake 5.1 too unless you use digital)