How do you turn off the file open warning in windows 7 (screenshot)?

[Intel+nVidiat]

this comes whenever i want to open a program like paint or even the start up programs:

http://i329.photobucket.com/albums/l362/kuklor/Untitled.png

I already turned UAC off.
I did AVG, Avast and Spybot S+D search.

 

[jasonicus]

If UAC is off, then you have/had a virus.