Cultured mesenchymal stem cells can "feel" at least several microns below the surface of an artificial microfilm matrix, gauging the elasticity of the extracellular bedding that is a crucial variable in determining their fate, researchers reported at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia. Controlling or predicting how stem cells differentiate into cells of a specific tissue type is a critical issue in the bioengineering of artificial tissue and in stem cell medicine... 
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