The Accord will get you better mileage than the Taurus by a long shot. Hondas can go almost 1500 miles on one tank of gas. Fords can barely do 1000-1100.
Both cars are subject to breakdowns but Hondas will outlast Fords by several years. Ford = Found On the Road Dead or F***ed Over Rebuilt Dodge. Honda parts can be found faster than Ford parts. Not all Taurus parts are like adult Legos, interchangeable. Some years don't match with others. Hondas usually match almost all years.
Take the Honda on your trip. You'll worry less, go farther on a tank of gas & spend less too.
Depends a lot on the mileage and how well the car has been taken care of. In general Hondas are more reliable that Fords, but if the Ford has lower mileage it might be the better bet.